Date: 26 November 2013
Secondary metabolites, 3D structure: Trivial name – Xanthone derived
Copyright: n/a
Notes:
Species: A. wentiiSystematic name: 9H-Xanthene-1-carboxylic acid, 3,8-dihydroxy-6-methyl-9-oxo-, methyl esterMolecular formulae: C16H12O6Molecular weight: 300Chemical abstracts number: 85003-85-6Selected references: Isolation and structures of four new metabolites from Aspergillus wentii. Hamasaki, Takashi; Kimura, Yasuo. Dep. Agric. Chem., Tottori Univ., Tottori, Japan. Agricultural and Biological Chemistry (1983), 47(1), 163-5. CODEN: ABCHA6 ISSN: 0002-1369. Journal written in English. CAN 98:122499 AN 1983:122499 CAPLUS
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Mr RM is 80 and an ex-coal miner.He developed pneumoconiosis from exposure to coal dust. He also developed rheumatoid arthritis and the combination of this disease and pneumoconiosis is called Caplan’s syndrome.
His chest Xray in early 2015 shows extensive bilateral pulmonary shadowing with solid looking nodules superimposed on abnormal lung fields, contraction of his left lung with an elevated diaphragm and a large left upper lobe aspergilloma, displaying a classic air crescent. His CT scan from mid 2014 demonstrates a large aspergilloma in a cavity on the left, with marked pleural thickening around it, which is partially ‘calcified’ towards its base. Inferiorly on other images,remarkable pleural thickening and fibrotic irregular and spiculated nodules are seen, most partially calcified.
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