Date: 26 November 2013
Further details
Image A. December 1991. The lesions were considered to be possibly malignant and surgically resected. Histological examination showed granulomata containing hyphae consistent with Aspergillus. Fungal cultures were not done.
Image B. June 1992 Despite resection of part of the right upper-lobe, invasive aspergillosis recurred six months later. Sputum cultures grew A.fumigatus and Aspergillus antibodies were detected in serum. He responded to itraconazole but subsequently progressed.
Image C. September 1992 Although the appearance suggests the formation of aspergillomas, the contemporaneous CT scan did not confirm this.
Image K. December 1991. There are no particular distinguishing characteristics of invasive aspergillosis. The right upper-lobe was resected and histological examination showed granulomata containing hyphae consistent with Aspergillus. Fungal cultures were not done.
Image M & N. CT scan of thorax. Post RVL segmentectomy with chronic pulmonary aspergillosis. CT shows patchy consolidation with cavitation in the apical segment of right lower lobe. A tiny pneumothorax can be identified posterolaterally (arrows).
Image O. Reference: Muco-cutaneous retinoid effects and facial erythema related to the novel triazole antifungal agent voriconazole. Denning, DW & Griffiths, CEM. Clin.Exp Dermatol 2001, 26(8), 648-53.
Copyright:
Courtesy of Dr D Denning, Wythenshawe Hospital, Manchester.(© Fungal Research Trust)
Notes: n/a
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Drug rashes: Drug interactions between steroids and anti-fungal drugs – (ecchymosis)
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Reference: Muco-cutaneous retinoid effects and facial erythema related to the novel triazole antifungal agent voriconazole. Denning, DW & Griffiths, CEM. Clin.Exp Dermatol 2001, 26(8), 648-53.
Courtesy of Dr D Denning, Wythenshawe Hospital, Manchester.(© Fungal Research Trust), ,
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Micrographs of A. niger conidia & conidial heads provided by Amaliya Stepanova, Head of Laboratory pathomorphology and cytology at Kashkin Research Institute, Russian Federation.
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Micrographs of A. terreus conidia & conidial heads provided by Amaliya Stepanova, , Head of Laboratory pathomorphology and cytology at Kashkin Research Institute, Russian Federation.
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Micrographs of A. fumigatus conidia & conidial heads provided by Amaliya Stepanova, , Head of Laboratory pathomorphology and cytology at Kashkin Research Institute, Russian Federation.
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Patients has history of ABPA complicating long standing asthma. His total IgE has fluctuated between 2,200 and 4,600 KU/L, his Aspergillus IgE between 36.3 and 65.4 kAU/L and Aspergillus IgG from 87-154 mg/L. He has been taking long term itraconazole.
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