ABPA Patient CC – Sputum sample and Bronchial biopsy: Presence of Charcot -Leyden crystals in sputum plug.

Date: 26 November 2013

  • Image A (& B) are right lung biopsies showing fragments of bronchial mucosa with a relatively heavy inflammatory cell infiltrate with prominent eosinophils. There is basement layer thickening and goblet cells are focally prominent.

  • Image B. Evidence of squamous metaplasia with reactive atypia. There is no evidence of granulomatous inflammation or malignancy. Congo red and Grocott stain revealed no fungal elements.

  • Image C. Lung biopsy tissue

  • Image D. Lung biopsy tissue

  • Image E. Mucous plug shows layering with eosinophilic debris and crystals (Images F & G). Plug has appearance of allergic mucin.

  • Image F. Mucous plug shows Charcot-Leyden crystals

  • Image G. Higher magnification of Charcot-Leyden crystals

  • Higher magnification of Charcot-Leyden crystals (from Image G)

Prev
Next

Images EF & G Mucous plug – Stains for fungal elements such as Grocott and PAS revealed no fungal elements. Appearance of specimens is consistent with allergic pulmonary fungal disease.

Despite the lack of fungal elements the histopathology is still indicative of ABPA.

Copyright: n/a

Notes: n/a

Images library