Neutrophils phagocytose conidia of Aspergillus fumigatus in an infected lung slice.

A Lys-EGFP mouse was treated as described for movie 4. The sequence shows highly active neutrophils (green) migrating through the lung tissue (blue) either carrying engulfed conidia (light blue) or being caught in the act of phagocytosis. Nuclei and NETs in the area are stained red (Sytox Orange). The average velocity of neutrophils in this experiment was 9.8 µm/min and 54% of cells were migrating at any time point (activity). Indicated is a scale bar and real time in minutes.
Reference: Production of Extracellular Traps against Aspergillus fumigatus In Vitro and in Infected Lung Tissue Is Dependent on Invading Neutrophils and Influenced by Hydrophobin RodA. Bruns et. al. PLoS Pathog. 2010 Apr 29;6(4):e1000873.
http://www.plospathogens.org/article/…

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