xanthomegnin

ID 2: 597

Toxin: y

Systematic name:

(8,8′-Bi-1H-naphtho(1,2-c)pyran)-1,1′,7,7′,10,10′-hexone, 3,3′,4,4′-tetrahydro-6,6′-dihydroxy-9,9′-dimethoxy-3,3′-dimethyl-, (3R,3’R)- (8CI)
(8,8′-BI-1H-NAPHTHO(2,3-c)PYRAN)-1,1′,6,6′,9,9′-HEXONE, 3,3′,4,4′-TETRAHYDRO-10,
(8,8′-Bi-1H-naphtho(2,3-c)pyran

Molecular formulae: 

C₃₀H₂₂O₁₂

Molecular weight: 574.488

Chemical abstract number: 1685-91-2

Chemical type: Dihydroisocoumarin

Literature reference:

• Durley RC, MacMillan J, Simpson TJ, Glen AT, Turner WB. Fungal products. Part XIII. Xanthomegnin, viomellin, rubrosulphin, and viopurpurin, pigments from Aspergillus sulphureus and Aspergillus melleus.
  J Chem Soc [Perkin 1]. 1975;(2):163-9.
  Stack ME, Mislivec PB. Production of xanthomegnin and viomellein by isolates of Aspergillus ochraceus, Penicillium cyclopium, and Penicillium viridicatum.
  Appl Environ Microbiol. 1978 Oct;36(4):552-4.

References URL: 

• http://pubchem.ncbi.nlm.nih.gov/compound/3032411

Aspergillus Species known to produce this metabolite:

• 561610

Toxicity:

Doses of 448 mg/kg body-weight in mice caused symptoms of liver damage including jaundice, necrotising cholangitis and other histological alterations.

Robbers JE, Hong S, Tuite J, Carlton WW. Production of xanthomegnin and viomellein by species of Aspergillus correlated with mycotoxicosis produced in mice. Appl Environ Microbiol. 1978 Dec;36(6):819-23.

Date uploaded: 2008-07-14 11:13:57

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Mycotoxin & Metabolites

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