territrem B

ID 2: 581

Toxin: n

Systematic name:

4H,11H-Naphtho(2,1-b)pyrano(3,4-e)pyran-1,11(5H)-dione, 4a,6,6a,12,12a,12b-hexahydro-4a,12a-dihydroxy-4,4,6a,12b-tetramethyl-9-(3,4,5-trimethoxyphenyl)-, (4aR,6aR,12aS,12bS)-
4H,11H-Naphtho(2,1-b)pyrano(3,4-e)pyran-1,11(5H)-dione, 4a,6,6a,12,12a,12b-hexa

Molecular formulae: 

C₂₉H₃₄O₉

Molecular weight: 526.575

Chemical abstract number: 70407-20-4

Literature reference:

• Ling KH, Yang CK, Peng FT. Territrems, tremorgenic mycotoxins of Aspergillus terreus. Appl Environ Microbiol. 1979 Mar;37(3):355-7.
  
  Chen JW, Luo YL, Hwang MJ, Peng FC, Ling KH. Territrem B, a tremorgenic mycotoxin that inhibits acetylcholinesterase with a noncovalent yet irreversible binding mechanism.
  J Biol Chem. 1999 Dec 3;274(49):34916-23.
  Chen JW, Ling KH. Territrems: Naturally Occurring Specific Irreversible Inhibitors of Acetylcholinesterase. J Biomed Sci. 1996 Jan;3(1):54-58.

References URL: 

• http://pubchem.ncbi.nlm.nih.gov/compound/114734

Aspergillus Species known to produce this metabolite:

• 561594

Toxicity:

mouse LD50 intraperitoneal 9060ug/kg (9.06mg/kg) Applied and Environmental Microbiology. Vol. 47, Pg. 98, 1984.
Link to PubMed

Date uploaded: 2008-07-14 10:46:53

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Mycotoxin & Metabolites

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