Mevinolin (lovastatin)

ID 2: 389

Toxin: n

Trivial name:

Butanoic acid, 2-​methyl-​, 1,​2,​3,​7,​8,​8a-​hexahydro-​3,​7-​dimethyl-​8-​[2-​(tetrahydro-​4-​hydroxy-​6-​oxo-​2H-​pyran-​2-​yl)​ethyl]​-​1-​naphthalenyl ester, [1S-​[1α(R*)​,​3α,​7β,​8β(2S*,​4S*)​,​8aβ]​]​-; (+)​-​Mevinolin; 6α-​Methylcompactin; Altocor; Altoprev; Antibiotic MB 530B; L 154803; Lestric; Lostatin; Lovacard; Lovalip; Lovastatin; Lovastatin lactone; Lovex; MK 803; MSD 803; Mevacor; Mevinacor; Mevinolin; Mevlor; Monacolin K; Monacolin K lactone; Sivlor

Systematic name:

[3,7-dimethyl-8-[2-(6-oxotetrahydropyran-2-yl)ethyl]-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2-methylbutanoate

Molecular formulae: 

C₂₄H₃₆O₄

Molecular weight: 388.54

Chemical abstract number: 75330-75-5

Literature reference:

• Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-​coenzyme A reductase and a cholesterol-​lowering agent. Alberts A W; Chen J; Kuron G; Hunt V; Huff J; Hoffman C; Rothrock J; Lopez M; Joshua H; Harris E; et al. Proceedings of the National Academy of Sciences of the United States of America (1980), 77(7), 3957-61.
  Process for the isolation of lovastatin. Hajko, Pavica; Vesel, Tanja; Radez, Ivan; Pokorny, Miroslav. PCT Int. Appl. (1994), WO 9429292 A1 19941222.
  Lovastatin production by solid state fermentation using Aspergillus flavipes. Valera, H. R.; Gomes, J.; Lakshmi, S.; Gururaja, R.; Suryanarayan, S.; Kumar, D. Enzyme and Microbial Technology (2005), 37(5), 521-526.
  The bioactive metabolites of Aspergillus versicolor F62 isolated from Haliclona simulans. Dong, Shihao; Gong, Ting; Zhu, Ping. Junwu Xuebao (2011), 30(4), 636-643.
  Production of lovastatin by Aspergillus parasiticus NCIM 696 using rice bran under solid state fermentation. Aparna, D. Geeta; Reddy, D. Sri Rami. Journal of Chemical, Biological and Physical Sciences (2012), 2(1), 284-291.
  Production and cytotoxicity studies of lovastatin from Aspergillus niger PN2 an endophytic fungi isolated from Taxus baccata. Raghunath, R.; Radhakrishna, A.; Angayarkanni, J.; Palaniswamy, M. International Journal of Applied Biology and Pharmaceutical Technology (2012), 3(3), 342-351.
  Bioprospect of lovastatin in Aspergillus spp. from University of Indonesia Culture Collection (UICC). Mangunwardoyo, Wibowo; Rajliyanti, Yanti; Kusmana, Dadang. World Applied Sciences Journal (2012), 16(2), 183-188.
  Analysis of lovastatin-​producing ability of fungi in Pu-​erh tea. Zhao, Zhen-jun; Tong, Hua-rong; Zhou, Li; Liu, Qin-jin. Shipin Kexue (Beijing, China) (2012), 33(12), 173-176.

References URL: 

• http://www.pnas.org/content/77/7/3957.abstract
• http://www.sciencedirect.com/science/article/pii/S0141022905001195
• http://www.jcbsc.org/journal/Paper/Vol_2_I_1_2011/V2I1_B13.pdf
• http://www.ijabpt.com/pdf/23050-Palaniswamy%20(1).pdf

Aspergillus Species known to produce this metabolite:

• /species/a-terreus
• /species/a-obscurus
• /species/a-oryzae
• /species/flavipes
• /species/a-versicolor
• /species/a-parasiticus
• /species/a-niger
• /species/a-flavus
• /species/a-wentii
• /species/a-tubingensis
• /species/a-fumigatus

Date uploaded: 2008-07-07 16:58:01

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Mycotoxin & Metabolites

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