aflatrem

ID 2: 76

Toxin: y

Systematic name:

4H-3,15a-Epoxy-1-benzoxepino[6′,7′:6,7]indeno[1,2-b]indol-4-one, 9-(1,1-dimethyl-2-propenyl)-2,3,5b,6,7,7a,8,13,13b,13c,14,15-dodecahydro-5b-hydroxy-2,2,13b,13c-tetramethyl-, (3R,5bS,7aS,13bS,13cR,15aS)-

Molecular formulae: 

C₃₂H₃₉NO₄

Molecular weight: 501.7

Chemical abstract number: 70553-75-2

Chemical type: Alkaloid

Literature reference:

• Indole metabolites from a strain of Aspergillus flavus. Cole, Richard J.; Dorner, Joe W.; Springer, James P.; Cox, Richard H. (Natl. Peanut Res. Lab., Sci. Educ. Adm., Dawson, GA 31742, USA). J. Agric. Food Chem., 29(2), 293-5 (English) 1981.
  Multiple toxin production by an isolate of Aspergillus flavus. Richard, J. L.; Gallagher, R. T. From Mycopathologia (1979), 67(3), 161-3.
  Aflatrem, the tremorgenic mycotoxin from Aspergillus flavus. Gallagher, Rex T.; Wilson, Benjamin J. From Mycopathologia (1979), 66(3), 183-5

References URL: 

• http://pubchem.ncbi.nlm.nih.gov/substance/135065615
• http://pubs.acs.org/doi/pdf/10.1021/jf00104a019?source=chemport&cookieSet=1&cookieSet=1&cookieSet=1&cookieSet=1
• http://www.sciencedirect.com/science/article/pii/S0040403900711786
• http://link.springer.com/article/10.1007/BF00470750

Aspergillus Species known to produce this metabolite:

• /species/a-flavus
• /species/a-minisclerotigenes

Toxicity:

The first tremorgenic mycotoxin to be isolated. An oral dose of 1 mg given to mice causes tremors, especially in response to attempts to move. The symptoms increase in severity after 1-2 h. but recovery usually occurs after 24-48 h.

Date uploaded: 0000-00-00 00:00:00

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Mycotoxin & Metabolites

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Aspergillus species produce a large number of secondary metabolites, sometimes referred to as extrolites. We attempt to list them all here and we also collect published papers.

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