aflatoxin B1

ID 2: 162

Toxin: y

Systematic name:

Cyclopenta[c]furo[3′,2′:4,5]furo[2,3-h][1]benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-4-methoxy-, (6aR-cis)-

Molecular formulae: 

C17H12O6

Molecular weight: 312.3

Chemical abstract number: 1162-65-8

Chemical type: Dihydrodifuranocoumarin

Literature reference:

  • Production of aflatoxin by the culture of strains of Aspergillus flavus-oryzae on sterilized peanuts. Codner, R. C.; Sargeant, K.; Yeo, R. Microbiol. Res. Estab., Porton, UK. Biotechnology and Bioengineering (1963), 5 185-92.
    Toxicity and fluorescence properties of the aflatoxins. Carnaghan, R. B. A.; Hartley, R. D.; O’Kelly, J. Nature (London, United Kingdom) (1963), 200(4911), 1101.
    Toxic metabolites of Aspergillus flavus. Hartley, R. D.; Nesbitt, Brenda F.; O’Kelly, J. Nature (London, United Kingdom) (1963), 198, 1056-8

References URL: 

Aspergillus Species known to produce this metabolite:

Toxicity:

Primarily an hepatotoxin and in some species, such as the rat and the rainbow trout, an hepatocarcinogen and mutagen. Toxic response depends on how the molecule is metabolised in the liver. Oral LD50 for adult male rat 7.2 mg/kg, adult dog 0.5 mg/kg and day-old duckling 0.35 mg/kg body-weight, respectively. Possibly associated with human liver cancer in association with hepatitis B infection.

Structure image:  

AflatoxinB1web

Date uploaded: 2008-07-07 13:06:04

Mycotoxin & Metabolites

Mycotoxin & Metabolite database

Aspergillus species produce a large number of secondary metabolites, sometimes referred to as extrolites. We attempt to list them all here and we also collect published papers.

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