9-deacetoxyfumigaclavine C

ID 2: 632

Toxin: y

Systematic name:

Not Known

Molecular formulae: 

C₂₁H₂₈N₂

Molecular weight: 308.5

Chemical abstract number: 1137244-08-6

Chemical type: Alkaloid

Literature reference:

• Bioactive Alkaloids from Endophytic Aspergillus fumigatus. Hui Ming Ge , Zhi Guo Yu , Jie Zhang , Jun Hua Wu and Ren Xiang Tan *. J. Nat. Prod., 2009, 72 (4), pp 753–755

References URL: 

• http://pubs.acs.org/doi/abs/10.1021/np800700e?cookieSet=1?cookieSet=1?cookieSet=1?cookieSet=1
• http://www.ncbi.nlm.nih.gov/pubmed/19256529
• http://pubchem.ncbi.nlm.nih.gov/compound/42640299

Aspergillus Species known to produce this metabolite:

• /species/a-fumigatus

Toxicity:

Cytotoxicity against KB (human nasopharynyeal epidermoid), MCF-7 (human breast adenocarcinoma), and K562 (human leukemia) cancer cell lines. It showed inhibition with an apparent selectivity for K562 cells, with IC50 values of 41.0 ( 4.6 ). It is noteworthy that the activity of metabolite 2 is close to that of doxorubicin hydrochloride (1.2 ( 0.2 μM), a presently prescribed drug for the treatment of leukemia.

Date uploaded: 2009-04-06 09:51:10

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Mycotoxin & Metabolites

Mycotoxin & Metabolite database

Aspergillus species produce a large number of secondary metabolites, sometimes referred to as extrolites. We attempt to list them all here and we also collect published papers.

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