α-sarcin

ID 2: 549

Toxin: n

Systematic name:

2-Amino-1-methyl-9H-purine-6-thione
9H-Purine-6-thione, 2-amino-1-methyl-
Purine-6(1H)-thione, 2-amino-1-methyl-
6H-Purine-6-thione, 2-amino-1,7-dihydro-1-methyl- (9CI)

Molecular formulae: 

C₆H₇N₅S

Molecular weight: 181.2

Chemical abstract number: 1320-87-2

Literature reference:

• Lin A, Huang KC, Hwu L, Tzean SS. Toxicon. 1995 Jan;33(1):105-10. Production of type II ribotoxins by Aspergillus species and related fungi in Taiwan.
  OLSON BH, GOERNER GL. ALPHA SARCIN, A NEW ANTITUMOR AGENT. I. ISOLATION, PURIFICATION, CHEMICAL COMPOSITION, AND THE IDENTITY OF A NEW AMINO ACID. Appl Microbiol. 1965 May;13:314-21.
  Kao R, Davies J. Fungal ribotoxins: a family of naturally engineered targeted toxins? Biochem Cell Biol. 1995 Nov-Dec;73(11-12):1151-9. Review.

References URL: 

• http://pubchem.ncbi.nlm.nih.gov/compound/3032391
• http://www.sciencedirect.com/science/article/pii/0041010194001404
• http://www.ncbi.nlm.nih.gov/pubmed/14325268
• http://www.ncbi.nlm.nih.gov/pubmed/8722032
• http://hub.hku.hk/handle/10722/157273

Aspergillus Species known to produce this metabolite:

• /species/a-giganteus
• /species/clavatus
• /species/a-oryzae-var-effusus
• /species/a-ostianus
• /species/a-tamarii
• /species/neosartorya-fischeri

Toxicity:

mouse LDLo 50mg/kg (50mg/kg) Journal of Medicinal and Pharmaceutical Chemistry. Vol. 5, Pg. 996, 1962.

Date uploaded: 2008-07-07 13:14:58

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Mycotoxin & Metabolites

Mycotoxin & Metabolite database

Aspergillus species produce a large number of secondary metabolites, sometimes referred to as extrolites. We attempt to list them all here and we also collect published papers.

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