New drugs in development for aspergillosis

New drugs for aspergillosis

• Alpha-asarone and fibrate-based analogues
• Alpha-asarone and fibrate-based analogues
• –
• Albaconazole
• Albaconazole, Isavuconazole and Ravuconazole
• –
• ASP2397
• ASP2397: Manufacturers website
• –
• CD101 IV (Biafungin, SP 3025) Echinocandin
• CD101 IV
• Long half life and Multiple species
• Multiple fungi are sensitive
• –
• E1210
• E1210
• –
• FG3622
• FG3622
• –
• F901318
• Discovery
• Activity
• –
• Macrocyclic amidinourea derivatives​
• Macrocyclic amidinourea derivatives
• –
• Nikkomycon Z
• Synergistic activity
• –
• NP213 & NP339
• NP213
• NP339
• –
• ​​Pradimicin A (BMS-181184)
• Pradimicin A structure
• –
• SCY-078 (Enfumafungin Derivative MK-3118)
• Enfumafungin Derivative MK-3118
• SCY-078 Manufacturer website
• Discovery
• Clinical activity
• –
• Toyama (T2307)
• Toyama (T2307)
• –
• VT-1158 & analogues
• VT-1158 (manufacturer website)

New approaches

• Nebulized Amphotericin B
• Nebulized Amphotericin B
• Review
• –
• Vaccine development
• BSA-conjugated mannan derived from C. albicans cell wall
• Review
• The Last Vaccine Frontier

Side effects of anti-fungal drugs

• Images
• Side effects of anti-fungal drugs (images)

Intracavitary amphotericin B

• Protocol
• Intracavitary amphotericin B