Immunoinformatics as a Tool for New Antifungal Vaccines

Detail:

Series: Methods in Molecular Biology | Volume: 1625 | Year: 2017 | Page Range: 31-43 | DOI: 10.1007/978-1-4939-7104-6_3

Year prepared: 2017

Immunoinformatics aids in screening for vaccine candidates, which can be experimentally tested for their efficacy. This chapter describes methods to use immunoinformatics to screen fungal vaccines candidates. Surface-localized molecules called adhesins could elicit immune response and serve as efficient vaccine candidates. The screening process is patterned on two steps, namely, a First Layer screen mostly used for value addition and prioritization based on characteristics of known antigens and a Second Layer highly focussed on core immunoinformatics analysis involving the binding and interactions of the molecules of the immune system. Together they offer a comprehensive objective evaluation of vaccine candidates selection in silico for fungal pathogens.

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