Ergolin-9-ol, 2-(1,1-dimethyl-2-propenyl)-6,8-dimethyl-, acetate (ester), (8β,9β)- (9CI); Fumigaclavine C (7CI); Indolo[4,3-fg]quinoline, ergolin-9-ol deriv.
Ergolin-9-ol, 2-(1,1-dimethyl-2-propenyl)-6,8-dimethyl-, acetate (ester), (8-beta,9-beta)-
Chem abstract number:
Ergot fungus. XLIX. Investigation on ergot alkaloids found in cultures of Aspergillus fumigatus. Yamano, Togo; Kishino, Kazuyuki; Yamatodani, Saburo; Abe, Matazo. Takeda Kenkyusho Nenpo (1962), 21, 95-101.
The clavine alkaloids, fumigaclavine A, a new alkaloid designated fumigaclavine C and several tremorgens belonging to the fumitremorgen group were produced by A. fumigatus strains isolated from molded silage. The LD50 of fumigaclavine C was about 150 mg/kg oral dose in day-old cockerels. Calves dosed with crude extracts of A. fumigatus cultures experienced severe diarrhea, irritability and loss of appetite. Postmortem examination showed serous enteritis and evidence of interstitial changes in the lungs; abnormal changes were not found in other tissues.
Species known to produce this metabolite:
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