Aspergillus fumigatus transcriptome reveals the reduction of metal metabolism and the increase of gliotoxin production during a disseminated murine infection

Mónica Sueiro‐Olivares1, Jimena V. Fernandez‐Molina1, Ana Abad‐Diaz‐de‐Cerio2, Xabier Guruceaga1, Andoni Ramirez‐Garcia1, Javier Garaizar2, Fernando Hernando1, Javier Margareto3, Aitor Rementeria1


Aspergillus fumigatus is considered to be the most prevalent airborne pathogenic fungus causing a wide range of diseases in immunocompromised patients. To succeed in the development of the infection, not only does this fungus have to evade and confront the immune system of the host to prevent being swallowed and killed, but it also has to cope with numerous microenvironments. This requires resilience against changes in pH and oxygen levels, and resistance to nutrient limitation and host derived proteins [1].
Murine models have represented a great breakthrough in the study of the pathogenesis of this fungus and even in antifungal therapy against aspergillosis in recent years. Their results enable the understanding of processes occurring during a real infection and might be extrapolated to human cases.



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7th Advances Against Aspergillosis