Acute Invasive Pulmonary Aspergillosis in the context of AML

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This 60 year old Caucasian male with a history of acute myeloid leukaemia (AML), diagnosed in 1999, developed probable pulmonary aspergillosis on June 13, 2000. Following repeated cycles of chemotherapy, the patient achieved remission. However, in late May 2000, the AML relapsed. He was diagnosed with invasive aspergillosis based on chest CT (inflammatory infiltrates) and consecutively postive galactomannan Aspergillus ELISA tests (1.9, 2.6, 1.5). After 10 days, he remained refractory to Amphotericin B and itraconazole, with progression of disease based on CT. He was treated with caspofungin for 4 days but died of respiratory failure.

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Case history