The Activity of FG3622 and FG3409 against Scedosporium spp

Ref ID: 15169

Author:

D. LAW, A. W. FOTHERGILL, S. C. CHEN, T. C. SORRELL, M. BIRCH

Author address:

1F2G, Manchester, United Kingdom, 2Univ. Texas Hlth. Sci Ctr, San Antonio, TX, 3Westmead Hosp., Sydney, Australia.

Full conference title:

50th Annual ICAAC

Date: 12 September 2014

Abstract:

Introduction: Since fungi of the genus Scedosporium spp. are frequently resistant to conventional antifungal agents, new agents active against these fungi are urgently required. FG3622 and FG3409 belong to a novel chemical class of antifungal agent with a novel mechanism of action. We have previously shown that these compounds are active against Scedosporium. In this study we extend these observations. Method: MICs were performed using a microdilution plate modification of the CLSI M38A2 method against 29 Scedosporium isolates comprising 8 S. prolificans, 14 S. apiospermum and 7 Scedosporium spp. and compared with MICs for 10 A. fumigatus isolates. MICs were carried out with FG3622 and FG3409; voriconazole and posaconazole were included as comparators. Results: The collated MIC data is shown in the table. Both FG3622 and FG3409 had excellent activity against the Scedosporium strains with FG3409 being the most potent of the drugs tested. Sixteen isolates had MICs >=4µg/ml against one or both azoles, however, in 15/16 isolates MICs for FG3622 and FG3409 were <=0.25µg/ml. All 8 S. prolificans isolates tested had high MICs both azoles (>8µg/ml) but had low MICs to FG3622 and FG3409 (GM 0.11 and 0.055 µg/ml respectively).

Conclusion: Both FG3622 and FG3409 demonstrate excellent activity against the majority of the Scedosporium isolates with FG3409 being the most active. Both compounds showed good activity against S. prolificans strains and other strains resistant to one or both of the azoles. These compounds may present future therapeutic options for treatment of infections with Scedosporium spp.

Abstract Number: F1-858

Conference Year: 2010

Link to conference website: NULL

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