Ref ID: 15169
Author:
D. LAW, A. W. FOTHERGILL, S. C. CHEN, T. C. SORRELL, M. BIRCH
Author address:
1F2G, Manchester, United Kingdom, 2Univ. Texas Hlth. Sci Ctr, San Antonio, TX, 3Westmead Hosp., Sydney, Australia.
Full conference title:
50th Annual ICAAC
Date: 12 September 2014
Abstract:
Introduction: Since fungi of the genus Scedosporium spp. are frequently resistant to conventional antifungal agents, new agents active against these fungi are urgently required. FG3622 and FG3409 belong to a novel chemical class of antifungal agent with a novel mechanism of action. We have previously shown that these compounds are active against Scedosporium. In this study we extend these observations. Method: MICs were performed using a microdilution plate modification of the CLSI M38A2 method against 29 Scedosporium isolates comprising 8 S. prolificans, 14 S. apiospermum and 7 Scedosporium spp. and compared with MICs for 10 A. fumigatus isolates. MICs were carried out with FG3622 and FG3409; voriconazole and posaconazole were included as comparators. Results: The collated MIC data is shown in the table. Both FG3622 and FG3409 had excellent activity against the Scedosporium strains with FG3409 being the most potent of the drugs tested. Sixteen isolates had MICs >=4µg/ml against one or both azoles, however, in 15/16 isolates MICs for FG3622 and FG3409 were <=0.25µg/ml. All 8 S. prolificans isolates tested had high MICs both azoles (>8µg/ml) but had low MICs to FG3622 and FG3409 (GM 0.11 and 0.055 µg/ml respectively).
Conclusion: Both FG3622 and FG3409 demonstrate excellent activity against the majority of the Scedosporium isolates with FG3409 being the most active. Both compounds showed good activity against S. prolificans strains and other strains resistant to one or both of the azoles. These compounds may present future therapeutic options for treatment of infections with Scedosporium spp.
Abstract Number: F1-858
Conference Year: 2010
Link to conference website: NULL
New link:
Conference abstracts, posters & presentations
-
Title
Author
Year
Number
Poster
-
v
Kimihide Muragaki1, Kenji Uehara1, Toru Takahashi2,3, Youhei Yamagata3 and Keietsu Abe1,3*
2011
NULL
n/a
-
v
Ryota Hattori , Mayumi Matsusita-Morita , Sawaki
Tada , Junichiro Marui , Ikuyo Furukawa , Satoshi Suzuki , Hitoshi Amano , Hiroki Ishida , Youhei Yamagata , Michio Takeuchi , Ken-Ichi Kusumoto2011
63)
n/a
-
v
Kiira Vuoristo, Kirsi Bromann, Mervi Toivari, Laura Ruohonen, Tiina Nakari-Setälä
2011
62)
n/a
-
v
Jakob B. Nielsen, Michael L. Nielsen, Christian Rank, Marie L.
Klejnstrup, Paiman Khorsand-Jamal, Dorte M. K. Holm, Bjarne G. Hansen, Jens C. Frisvad, Thomas O. Larsen and Uffe H. Mortensen2011
61)
n/a
-
v
Uffe H. Mortensen, Michael L. Nielsen, Jakob B. Nielsen,
Christian Rank, Marie L. Klejnstrup, Dorte K. Holm, Katrine H. Brogaard, Bjarne G. Hansen, Jens C. Frisvad, Thomas O. Larsen2011
NULL
n/a
-
v
Marie Louise Klejnstrup*, Morten
Thrane Nielsen, Jens Christian Frisvad, Uffe Mortensen, Thomas Ostenfeld Larsen. Department of Systems Biology,2011
NULL
n/a
-
v
Dorte K. Holm, Bjarne G. Hansen, Thomas O. Larsen, Uffe H. Mortensen
2011
NULL
n/a
-
v
.Outi M. Koivistoinen, Peter Richard, Merja Penttilä, Dominik
Mojzita2011
56)
n/a
-
v
Thomas O. Larsen*, C.
Rank, M. Klejnstrup, M.L. Nielsen, J.B. Nielsen, D.M.K. Holm, K.H. Brogaard, B. Hansen, J.C. Frisvad and U.H. Mortensen.2011
55)
n/a
-
v
Christian Rank*, Marie Louise Klejnstrup, Lene Maj Petersen, Jens Christian Frisvad,
Thomas Ostenfeld Larsen.2011
54)
n/a