Microbiology from bronchoscopy in haematologic patients: comparison of stem cell recipients with nonrecipients

Ref ID: 17702

Author:

J.C. Kwon*, S.Y. Cho, S.H. Kim, S.H. Park, S.M. Choi, D.G. Lee,
J.H. Choi, J.H. Yoo

Author address:

(Seoul, KR)

Full conference title:

22nd European Congress of Clinical Microbiology and Infectious Diseases

Abstract:

Objectives: We investigated microbiologic results of bronchoscopy
(BRS) in haematologic patients with pneumonia and compared
microbiology from haematopoietic stem cell recipients (HSCRs) with
that from non-recipients (non-HSCRs).
Methods: We retrospectively reviewed medical records of consecutive
haematologic patients who experienced BRS from APR 2009 to AUG
2011 at the Catholic haematopoietic stem cell transplantation centre in
Korea.
Results: A total of 176 cases were identified. Mean age was
47.7 ± 15.4 years, and 122 patients (69.3%) were men. Underlying
diseases were acute myelogenous leukemia (n = 65, 36.9%), acute
lymphoblastic leukemia (n = 24, 13.6%), myelodysplastic syndrome
(n = 26, 14.8%), etc. HSCR group accounted for 48.9% (n = 86), of
which 87.2% (n = 75) were allo-HSCR. The number of culture-positive
bacterial, fungal, and tuberculosis (TB) cases from brohchoalveolar
lavage (BAL) were 44 (25.0%), 5 (2.8%), and 11 (6.3%), respectively.
Acinetobacter baumannii (n = 10) was the most common bacterial
isolate followed by methicillin-resistant Staphylococcus aureus (n = 9)
and coagulase negative staphylococci (n = 6). Four Aspergillus, one
Rhizopus and five non-TB mycobacterial cases were identified.
Pneumocystis jiroveci polymerase chain reaction (PCR) was positive
in 32 cases (18.2%). Multiplex PCR for respiratory viruses were
performed in 147 cases, of which 21.1% (31/147) were positive.
Respiratory synctivial virus (n = 11) was the most common virus
followed by human rhinovirus (n = 10), parainfluenza virus (n = 9),
influenza A (n = 4) and metapneumovirus (n = 1). In four cases, two
different viruses were positive. One hundred thirty one cases were

Abstract Number: P2120

Conference Year: 2012

Link to conference website: NULL

New link: NULL

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