Inhibitory effect of aspirin and diclofenac treatment on some non-albicans Candida species

Ref ID: 17752

Author:

E. Rusu, C.D. Cristescu, A. Boiangiu*, I. Avram, D. Pelinescu,
T. Vassu

Author address:

(Bucharest, RO)

Full conference title:

22nd European Congress of Clinical Microbiology and Infectious Diseases

Abstract:

The most common organisms implicated in fungal infections are
species of Candida, which are under normal circumstances in
commensally relation with human host. While Candida parapsilosis
is common in neonatal and pediatric age group, C. glabrata and C.
krusei infections are becoming more frequent in the elderly population.
Objectives: The main goal of our study was to evaluate aspirin and
diclofenac sodium antifungal activity and in vitro susceptibility of some
non-albicans Candida strains to these non-steroidal anti-inflammatory
drugs.
Methods: Eight yeast strains were isolated from pharyngeal and
vaginal secretions. Strains were identified by conventional and
biochemical test as: one strain C. glabrata, three strains C.
parapsilosis and four strains C. krusei. Tests of viability cells in the
presence of 2 mg/mL aspirin and diclofenac sodium were done by the
microdilution method.
Results: Our results showed an antifungal activity of both nonsteroidal
anti-inflammatory drugs against tested strains. Viability
reduction in presence of aspirin was 48% for C. glabrata, between
30-68% for C. parapsilopsis strains and between 20-65% for C. krusei
strains. For diclofenac sodium the results were similar, viability strains
decreased with 50% for C. glabrata strain, 35-75% for C. parapsilosis
strains and 23-60% for C. krusei strains. The greatest inhibitory effect
that we observed was on C. parapsilosis strains in the presence of
aspirin and C. krusei strains in the presence of diclofenac. Antifungal
effect was strain depending.
Conclusions: According to our results, aspirin and diclofenac sodium
have inhibitory activity against some non-albicans strains: C.
parapsilosis, C. krusei and C. glabrata. These data underline the
potential utility of these drugs in the management of fungal infections.
The anti-inflammatory and analgesic properties of sodium diclofenac
and aspirin might represent an additional advantage for their use in the
management of infection with Candida species.
Keywords: viability, anti-inflammatory, antifungal effect
Acknowledgements: This work has been supported by the national
research project CNCSIS Human Resources TE66/2010.

Abstract Number: NULL

Conference Year: 2012

Link to conference website: NULL

New link: NULL

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