Importance of Aspergillosis of the paranasal sinuses

Author:

B. Sadeghinejad1; S. Nikakglagh2

Author address:

1Abadan School of Medical Sciences, Abadan, Iran; 2Emam Khomeiny Hospital,
Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Full conference title:

8th Trends in Medical Mycology, Organised under the auspices of EORTC-IDG and ECMM, 6-9 October 2017, Belgrade, Serbia

Date: 11 October 2017

Abstract:

Objectives: Nowadays, due to the increasing number of immunocompromised patients, the occurrence of mycoses infections have been increased and fungal sinusitis usually is observed in weakened immune system individuals but may be appear in healthy people. Aspergillosis of the paranasal sinuses has classified in two original groups, non-invasive “aspergilloma” form and invasive form that usually seen in the immunosuppressed patienst. In this study 34 sinusitis patients attending to department of ENT, Emam Khomeiny Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran were evaluated. Methods: Fungal sinusitis was diagnosed based on clinical findings, functional endoscopic sinuses surgery (FESS) of nasal and paranasal sinuses, CTscan and MRI, Mycological and histopathological examinations. Results: In histopathological and mycological examinations of tissue specimens endoscopic sinuses of nasal and paranasal, in 7 cases out of 34 cases was observed hyaline, branching septate hyphae with conidiophores and conidia in crusted fungus ball samples. In cultured, Aspergillus flavus and Aspergillus niger were isolated. Microscopically, stained smears from colonies with lactophenol anillin blue showed conidiophores and the conidia of As. flavus and As. niger. In this study fungal sinusitis was reported in individuals which were diabetic and immunosuppress such as kidney transplantation, leukemia and record of nasal polyp surgery and allergic chronic sinusitis. All cases were successfully treated with surgical debridement involved tissue and systemic Amphotricin B. Conclusion: We confirmed the importance of early clinical diagnosis and treatment with surgical debridement of infected tissue in nasal cavity and paranasal sinuses combined with Amphotricin B in special patients such as diabetic individuals as soon as possible. Key words: Fungal sinusitis, Aspergillosis, paranasal sinuse.

Abstract Number: P220

Conference Year: 2017

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