Differences in clinical characteristics between aspergillus fumigatus sensitized asthmatics and allergic bronchopulmonary aspergillosis

Author:

Haisheng Hu

Author address:

China

Full conference title:

European Academy of Allergy and Clinical Immunology Congress 2019

Date: 20 August 2020

Abstract:

Background
Aspergillus fumigatus sensitized asthma patients (AFSA) are prone to develop into allergic bronchopulmonary aspergillosis (ABPA). This study aims to explore the characteristic of these patients and accurate diagnosis between diseases.

Method
The sIgE of Aspergillus fumigatus was detected by ImmunoCAP 1000 system in 17 patients with ABPA and 14 patients with AFSA. The sIgG of Aspergillus fumigatus was detected by Aspergillus fumigatus specific IgG ELISA kit (DRG). Clinical data such as pulmonary function and blood routine were collected.

Results
There was no significant difference in blood routine and induced sputum between ABPA and AFSA patients, but the levels of sIgG [2294.00 U/mL (1527.00, 14170.00) vs. 972.60 U/mL (650.90, 1792.00)], sIgE [8.77 kU/L (1.64, 16.85) vs. 1.04 kU/L (0.70, 2.05)] in ABPA patients were significantly higher than those in AFSA patients (P < 0.05). Aspergillus fumigatus sIgG was strongly correlated with Aspergillus fumigatus sIgE (rs = 0.797, P < 0.001) in ABPA patients , but weak in AFSA patients. When combined with Aspergillus fumigatus sIgE (> 1.00 kU/L) and Aspergillus fumigatus sIgG (> 1000.00 U/mL) for the differential diagnosis of ABPA and AFSA, the sensitivity and specificity reached 82.3% and 78.6%

Conclusion
ABPA patients have higher levels of sIgE and sIgG of Aspergillus fumigatus than AFSA patients. Combination of sIgE and sIgG of Aspergillus fumigatus to diagnosis ABPA and AFSA patients is important.

Abstract Number: TP1509

Link to conference website:

Link Conference abstract: 

EAACI 2019

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