Detection of Aspergillus antigen galactomannan in diagnosis and follow-up of the Aspergillus infections

Ref ID: 17703

Author:

P. Kazila*, I. Diamanti, E. Sotiriadou, V. Anagnostou, X. Meleti,
S. Kostopoulou, S. Karampa, E. Kaitsa

Author address:

Thessaloniki, GR)

Full conference title:

22nd European Congress of Clinical Microbiology and Infectious Diseases

Abstract:

Objectives: The invasive aspergillosis (IA) remains a common cause
of morbidity and mortality in immunocompromised patients, although
there is a lot of progress in diagnosis and therapeutic management. Aim
of our study is to evaluate the detection of Aspergillus antigen
galactomannan (GM) in diagnosis and following up in infected patients
of our hospital.
Methods: During the period 2008-2010, 2499 clinical samples were
examined for the detection of GM antigen. Samples (1-8/patient) were
from 422 immunocompromised hospitalized patients. Patients were
mostly neutrophenic with symptoms of infection. GM antigen was
detected by Platelia Aspergillus EIA method (Biorad, Marnes-La-
Coquette, France). Samples that had ratio (r) >0.5 were rated as
positive. Statistical analysis was made using SPSS (paired samples ttest).
Results: The positive samples were 133/2499 (5.32%). These samples
were from 71/422 (16.8%) patients. Apart from GM there were other
clinical and laboratory findings that confirmed aspergillosis. Fifty-eight

Abstract Number: R2726

Conference Year: 2012

Link to conference website: NULL

New link: NULL

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