Azole resistant Aspergillus fumigatus from agricultural settings

Author:

M Momany1, M Brewer2, SE Kang1, LG Sumabat2, T Melie2, B Mangum1

Author address:

1Fungal Biology Group and Plant Biology Department, University of Georgia, Athens, USA
2Fungal Biology Group and Plant Pathology Department, University of Georgia, Athens, USA

Full conference title:

9th Advances Against Aspergillosis

Date: 27 February 2020

Abstract:

Purpose: Azoles are widely used in agriculture to combat fungal pathogens of plants and in the clinic to combat fungal pathogens of people. Resistance to clinical antifungals has become a major problem in India and Europe in the last decade.  Recently there has been an increase in azole-resistant Aspergillus fumigatus isolated in clinics in the U.S., but the prevalence of azole-resistant A. fumigatus in the environment is not well-understood. 

Methods: We sampled 56 agricultural sites in Georgia and Florida, including many with known past azole exposure. MICs for clinical azoles were determined. Microsattelites and whole genome sequencing were used to anlayze strains.

Results: We isolated over 100 strains that grew on low levels of tebuconazole, including several that were resistant to high levels of clinical azoles in microbroth dilution tests. 

 

Conclusion: Microsatellite and whole genome sequencing suggest that clinical azole resistance has an agricultural origin.

Abstract Number: 176

Conference Year: 2022

Link Conference abstract: 

AAAM 2020

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