Antifungal drug interactions database

Ref ID: 17701

Author:

G.T. Atherton*, N. Atherton, H. Le Sueur, D.W. Denning

Author address:

(Manchester,
Lancaster, Newcastle upon Tyne, UK)

Full conference title:

22nd European Congress of Clinical Microbiology and Infectious Diseases

Abstract:

Objectives: Antifungal drugs are often taken for a long period of time
and are capable of interacting with a wide range of other medications
e.g. the azole group of antifungals are a substrate and inhibitor of
cytochrome P450 (CYP) which is important for the elimination of many
other drugs. These interactions can in some cases cause serious
alterations in the effective dose of either the antifungal drug or the
concomitant medication.
Doctors and pharmacists experience with oral or IV antifungal drugs
can be limited so information provided to the patient on possible
interactions runs the risk of being incomplete. In addition several
antifungals have not been in use fpr a long time and new interactions
are still being discovered. There is a need for a single central resource to
hold all interaction data for this class of drugs.
Method: The Aspergillus Website is one of the best used and most
highly ranked websites that provide information on the treatment of aspergillosis and support to patients. The website is run by a team
closely associated with the National Aspergillosis Centre (NAC),
Manchester, UK. It therefore has ready access to relevant clinical advice
and is already established as a well used route of communication for
medical information and support for aspergillosis. We set out to provide
a database in which all currently known interactions with antifungal
drugs are recorded.
A four level colour system is used and designed for patients; white – no
interaction, green – minor interaction, orange – moderate interaction,
needs medical input and red – significant interaction, needs urgent
medical assessment. The text related to each interaction explains the
reason for the interaction and suggests ways of circumventing it.
Addition of new information is a regular ongoing process using new
scientific papers and our own clinical experience at the NAC as a guide.
Results: We launched the Antifungal Drug Interaction database
(www.aspergillus.org.uk/nac/interactions/patientchoosegeneric.php) in
July 2011 with 708 concomitant drugs and six antifungals covered;
itraconazole, voriconazole, posaconazole, micafungin, amphotericin B
and caspofungin.
In its first three months of operation the database was used over 1300
times.
Conclusions: The Antifungal Drug Interactions database has been well
received, suggesting that it is useful and easy to use, and that the
information is a valuable addition to the support we offer patients and
doctors.

Abstract Number: P2104

Conference Poster: y

Conference Year: 2012

Link to conference website: NULL

New link: NULL

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