Allergic bronchopulmonary aspergillosis in allergic diseases sensitized with mold: single center experience

Author:

Demirturk, M; Isik, SR; Unal, D

Author address:

Yedikule Training and Research Hospital, Istanbul, Turkey

Full conference title:

European Academy of Allergy and Clinical Immunology Congress 2016

Abstract:

Background: Exposure to fungal allergens may cause allergic diseases and worsen the existing allergic diseases. Although there are many kinds of fungal allergens, indoor allergens such as Aspergillus fumigatus and Penicillium sp, and outdoor allergens such as Alternaria alternate and Cladosporium sp are the allergens that are mostly related to allergic diseases.

Method: The patients who had fungal allergy and came to Adult Allergy Outpatient Clinics last year were included in the study. Two hundred and thirty-four patients who had positivity in the skin test to one or more fungus (Alternaria alternate, Aspergillus fumigatus, Penicillium sp) were examined retrospectively and were grouped according to their relations with the allergic diseases and outdoor and indoor type of fungus. Among these patients, those who had the ABPA diagnostic criteria according to Agarwal et al classification were detected.

Results: Out of 234 patients 88 (37.6%), 102 (43.6%) and 136 (58.1%) had positivity for Alternaria, Aspergillus and Penicillium respectively. Ninety-five patients were male and 139 female (%40.6/59.6). Mean age of male and female were 40.8  2.5, 41.2  2.2 respectively. One hundred and thirteen (48.3%) patients had only allergic rhinitis, 42 (17.9%) only asthma and 79 (33.8%) had both allergic rhinitis and asthma. Five patients were diagnosed with ABPA according to Agarwal criteria. While five of those patients with ABPA had sensitivity with aspergillus, three of them had positivity with all three fungus. The total IgE value of the patients with ABPA was 1173 IU/l. There were 4 males and one female among those patients with ABPA. No significant difference was detected between indoor and outdoor fungus allergens regarding with allergic rhinitis and asthma. Penicillium sensitivity was found to be an independent risk factor affecting the allergic disease (CI (0.20–0.66) r: 0.24, P: 0.001)

Conclusion: Penicillium allergy seems to be a risk factor for allergic diseases for adults. ABPA development can be due to aspergillus sensitivity. In addition, ABPA should be noticed in patients with severe asthma.

Abstract Number: 1179

Conference Year: 2016

Link Conference abstract: 

EAACI 2016

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