Disseminated aspergillosis following a bone marrow transplant

Submitted by: Michael on: 16 April 2013

Case number: 56

Summary:

A 15-year-old Caucasian male with Wiskott-Aldrich syndrome underwent an allogeneic bone marrow transplant. His post transplant course was complicated by graft-versus-host disease. The patient developed disseminated (lung, skin, brain and vertebral body) aspergillosis, with culture confirmation. The patient received 236 days of therapy with various agents including lipid formulations of amphotericin B, 17 days of voriconazole and 71 days of caspofungin prior to starting micafungin in combination with AmBisome. He eventually received a partial response.

Species (if applicable): Aspergillus fumigatus

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Choose aspergillosis groupingAcute invasive pulmonary aspergillosisAllergic aspergillosisAspergillomaChronic cavitary pulmonary aspergillosisOther invasive diseaseOther types of aspergillosisPaediatric AspergillosisPleural AspergillosisPrimary pulmonary aspergillosisSevere Asthma with Fungal SensitisationSinus aspergillosis in non-immunocompromisedSubacute invasive (chronic necrotizing) pulmonary aspergillosis