Undescribed specialised metabolites from the endophytic fungus Emericella sp. XL029 and their antimicrobial activities.
Author:
Xian PJ, Liu SZ, Wang WJ, Yang SX, Feng Z, Yang XL.
Date: 1 July 2022
Abstract:
The fungus Emericella sp. XL029 isolated from leaves of Panax notoginseng was investigated for agents with potential antibacterial and antifungal activities using a one strain-many compounds (OSMAC) strategy. Fifteen compounds, including seven undescribed structures, were obtained from this species. Their structures were confirmed by extensive spectroscopic data, single-crystal X-ray crystallography and quantum chemistry calculations. Emerlactam A exhibited better antibacterial activity against multidrug-resistant Enterococcus faecium and antifungal activity against Helminthosporium maydis, with an MIC value of 12.5 μg/mL. Quiannulatic acid displayed significant antibacterial activity against multidrug-resistant Enterococcus faecium and multidrug-resistant Enterococcus faecalis with MIC values of 1.56 μg/mL and 3.13 μg/mL, respectively. 5-alkenylresorcinol exhibited significant antifungal activity against all tested phytopathogenic fungi with MIC values ranging from 6.25 to 12.5 μg/mL.
Keywords: Antibacterial activity; Antifungal activity; Araliaceae; Emericella sp.; OSMAC strategy; Panax notoginseng; Trichocomaceae.
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