Author:

Ren H, Liu R, Chen L, Zhu T, Zhu WM, Gu QQ

Date: 20 May 2010

Abstract:

Two new hetero-spirocyclic gamma-lactams, azaspirofurans A (1) and B (2), had been isolated from a marine sediment-derived fungus Aspergillus sydowi D2-6. Their structures were determined by the chemical evidence and spectral analyses. Compound 1 exhibited cytotoxicity against A549 cell line with the IC50 value of 10 microM by MTT method.

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