Author:

Huang HB, Feng XJ, Liu L, Chen B, Lu YJ, Ma L, She ZG, Lin YC

Date: 16 June 2010

Abstract:

Three new dimeric naphtho- gamma-pyrones, named rubasperone A (1), rubasperone B (2), and rubasperone C (3), together with two known compounds, rubrofusarin (4) and rubrofusarin B (5), were isolated from the mangrove endophytic fungus ASPERGILLUS TUBINGENSIS (GX1-5E). Their structures were determined by spectroscopic methods, including IR, MS, and 1D and 2D NMR. The structures of 1 and 2 were further confirmed by X-ray crystallography. In the bioactivity assays against tyrosinase and alpha-glucosidase, rubrofusarin (4) exhibited moderate tyrosinase inhibitory activity, with an IC (50) value of 65.6 microM, and rubasperone C (3) showed mild alpha-glucosidase inhibitory activity, with an IC (50) value of 97.3 microM.

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