LIVING WITH IT WORKING WITH IT TREATING IT
Nearly 5000 very fine photographs; well worth the visit.
The “First Nature” Multimedia Guide to Fungi features over 1000 pictures with details of hundreds of beautiful and fascinating mushrooms and toadstools on an interactive CD-ROM for PCs with Internet Explorer. Well worth buying. The website is well worth visiting for the numerous pictures of fungi as well as many other groups of organisms – insects, fish, amphibians, reptiles, birds, bats, land mammals, wild flowers and trees.
Roger Phillips' twenty-year study makes this site the most complete collection of photographs and mushroom information from both sides of the Atlantic ever assembled. We already have over 3000 images on our site to help you identify and learn more about the mushrooms of Europe and North America! RogersMushrooms is now completely free to access!
Website of the Fungal Cell Biology Group at the University of Edinburgh. The main focus of research is on developmental pathways resulting from conidial germination and the early stages of colony establishment in the fungal model Neurospora crassa and the human pathogen Aspergillus fumigatus. Much of the research involves analysing living cells using a wide range of advanced imaging and measurement techniques and the site is superbly illustrated with video and photographic results of these analyses.
You should be able to find everything you wanted to know about fungi by clicking on the on the links on the images or on the text links. Tom promises to leave his pages at this site for a long time, and points out that you can always find them by typing (no spaces) into your browser.
Statins are a group of cholesterol lowering drugs that account for around 40% of prescribed drugs by GPs in the UK. The statin manufacturing industry is worth billions of dollars and is a growing industry. The link between increased LDL-cholesterol levels and the chances of developing coronary heart disease (CHD) has long been acknowledged. Given the high cost of CHD to the NHS (in 1985-86 it is estimated to have cost £390 million ), ways of reducing the burden are likely to become more and more necessary. In the UK, coronary heart disease (CHD) is responsible for 28% of all deaths, and 33% of deaths in men under 65 years old, making it the leading cause of death. Globally, CHD is also set to become a much larger threat. Whilst in 1990 pneumonia, diarrhoeal disease and perinatal conditions were the leading causes of death, it is predicted that by 2020 heart disease, depression and road traffic accidents will be the three greatest killers world wide.
This mycoses page is intended to give students (or anyone who's interested really!) some insight into the clinical aspects of mycology. This page covers an area of mycology which is more immediately interesting to most people.
Here you'll find details of diseases, the organisms that cause them, symptoms, and treatments. Hope you find the journey useful.
In informal terms there are three major groups of fungi:
Whilst they all have different properties, they generally all share the key feature of the fungal lifestyle, which is the ability to decay organic matter as a means of accessing the nutrients that waste materials contain (saprotrophism).
In fact the recycling ability of fungi is the area that holds the prime interest for scientists today. Lignin is one of three components of plant cell walls (the others being cellulose and hemicellulose), and is a complex polymer which provides the strength and support in the secondary growth of perennial plants like bushes and trees; it is part of the woody tissue that makes timber as we know it. However, lignin is a complex polyphenolic; whilst it is of great use to all plants, it is a major problem for most microorganisms that try to access the nutrients inside the plant, but are foiled by the phenolic antiseptics released by any attempt to degrade its lignocellulose protective barrier. In fact, there is only one type of microorganism that can degrade lignin…and , yes, you guessed it…it's the fungi.
The concepts and beliefs of Chinese Medicine are collated, discussed and compared to the Western approach to treatment. Fungi and their innate properties are briefly examined and their structure summarised. The reports available on Auricularia are studied and the scientific evidence separated, dissected and investigated. Then the claims made of Auricularia are considered in conjunction with the evidence from scientific reports. This enables an exploration as to their reliability.
The distinct absence of any scientific experimentation is considered in relation to both its reported healing properties and the recent competition or even possible replacement by more Western remedies. There appears to be a great disparity between the bold claims made in the literature and any evidence of its use. However the distinct decline in its prominence in the market place could easily be attributed to its perception as a fashionable treatment waning, and thus lead directly to its subsequent replacement by more popular remedies. Whatever potential Auricularia may hold, its continued study seems unlikely when contemplating the combination of its diminished use and the progression towards Westernisation throughout China.
My name is Jonathan Dixon and as a final year undergraduate student at the University of Manchester (UK) in 2001 I designed the original version of this website on Fungal Evolution for my final year project. It has been updated in 2011 and is primarily aimed at undergraduates in biological sciences, but anyone with a keen interest in fungi may find it useful and appealing. I decided to split the topic of fungal evolution into three main headings, however there is no order or dominance to any one grouping, so you can view them as you wish. They are:
Kingdom Fungi: This section briefly describes whereabouts fungi lies in the six kingdoms of life. It includes descriptions of all kingdoms, emphasizing, of course, on the broad definition of fungi.
Diversification: The kingdom fungi is split into 4 main phyla. This section includes knowledge regarding these phyla, as well as information on those organisms that have one time or another been confused with fungi.
Origins of fungi: Under this heading you will find information regarding the actual times of fungi divergence and the methods involved to find out such evolutionary dates.
You will also find useful bibliography, links and glossary pages.
承蒙遠東及香港區共濟會之菲裘新研究東亞學科基金的贊助，使這部以中文介紹真菌生理、生化、遺傳、細胞學、發育和形態的資料可出版，著者深致謝意! 特別鳴謝W. Bro. Peter J. Nunn 的支持。
The authors are deeply grateful to The Freemasons’ Fund for East Asian Studies by the District Grand Lodge of Hong Kong and the Far East, without which this publication would not have been possible. We are especially grateful to Mr. W. Bro. Peter J. Nunn, District Grand Secretary of the Fund for the kind support. Recently there have been a few mycology books been published. The information is overwhelming. In order to give a precise and concise introduction on fungal morphogenesis, the authors adopt an illustrative approach. In this webpage, relevant mycological websites is included for the readers to update information resource and/or participate in discussion forum.
This is an interactive website of general fungal biology that covers the whole range of mycology
Chinese traditional medicine uses a variety of natural products to treat illness, many of which have no sound medical reasoning. In this study I am to assess the evidence for and against the use of a particular fungus called Cordyceps chinensis, to determine whether or not there is any hard science to its curative effect or whether it is just blind faith. I found some promising material on the effects of the fungus especially in the use of athletics where field tests have been performed. The problems encountered were the reliability of the claims. This was because of where the information was gathered e.g. internet and Chinese journals, where we have to be a little sceptical whether the tests and reports have been properly monitored and checked. In conclusion I found that the use of this fungus medically seems bright but more controlled investigations need to be performed, especially in the West to dispel the myths about traditional chinese medicine.
Discovery of cyclosporine in 1971 began a new era in immunopharmacology. It was the first immunosuppressive drug that allowed selective immunoregulation of T cells without excessive toxicity. Cyclosporine was isolated from the fungus Tolypocladium inflatum. Cyclosporine was first investigated as an anti-fungal antibiotic but its spectrum was too narrow to be of any clinical use. J. F. Borel discovered its immunosuppressive activity in 1976. This led to further investigations into its properties involving further immunological tests and investigations into its structure and synthesis. Cyclosporine has unwanted side effects, notably nephrotoxicity. Animal testing showed cyclosporin to be sufficiently non-toxic to begin clinical trials. These initially failed due to poor absorption of the drug. Once this had been overcome, results were encouraging enough for cyclosporine to be licensed for use in clinical practice. There is some controversy between Borel and other workers over priority in the discovery of cyclosporine and its pre-clinical development, which is examined in this review. Cyclosporine changed the face of transplantation. It decreased morbidity and enabled the routine transplantation of organs that until then had only been done experimentally.
Research on Ganoderma is briefly reviewed. The mushroom’s antitumour, cardiovascular, immunomodulatory and anti-HIV effects were critically evaluated. Each paper read was partly judged on the reliability of the journal in which it was published; so-called "impact factors" being used as a measure of credibility.
Theoretical evidence raises the possibility that Ganoderma does have medicinal potential, however there is a lack of reliable clinical evidence to support this.
Fungi for better health and environment [downloads a PDF presentation showing an overview of fungi, their place in the natural world and impact on human affairs.]
The discovery of Diflucan (fluconazole) was a major landmark in the pharmaceutical industry, as it was the first antifungal drug to be developed that could be used both orally, for minor infections such as candidiasis, or intravenously for more serious systemic infection like cryptococccal meningitis.
Fluconazole development was based on two initial assumptions by the scientists involved: firstly that drugs should be tested in experimental models of infections, and secondly that a polar molecule might have superior pharmacological properties. The developers took these two ideas as a starting point and went through a rigorous process to find the right compound. Eventually they came across 2-(2,4-difluorophenyl)-1,3-bis (1H-1,2,4-triazol-1-yl)-2-propanol, that is fluconazole. This report details the progressive discovery of fluconazole and all the intermediate steps and compounds found along the way. The report also describes the general development of drugs, the history of antifungal agents of the past and examines the major agents currently available. There is also a section devoted to the clinical and pharmacological profile of fluconazole, and any considerations concerning the future development of antifungal agents.
The medicinal value of shiitake is not really well appreciated in Western medicine, though it has a long history as a valuable remedy in traditional Asian medicine. Research on the chemicals present in Lentinula edodes seems to be revealing medical products and it may become a valuable resource in fighting diseases.
Ask about fungi and people think about fine specimens like these guys:
Ask to what they are related and you'll probably find that some people think fungi are plants...others think they might be bacteria.
‘How many of you think that fungi are bacteria?’ is a question posed at a recent Summer School for year 10 pupils (4th year in secondary school, and about 16 years of age at the time), by one of the pupils who had attended a workshop session of ours. When all attendees (approximately 170 pupils) were asked 'Hands up all those who think fungi are plants', about 15 hands went up, but when asked 'Hands up all those who think fungi are bacteria', at least 150 hands went up!
As teachers we are used to battling against the mistaken idea that fungi are plants, but it was a shock to find that so many pupils believe that fungi are bacteria so close to the end of their statutory education. After all, it’s a bigger error than for them to think that whales are fish; at least whales and fish are in the same biological Kingdom. Does such ignorance matter? We say it does. The practical reason it matters is because the activities of fungi are crucially important in our every day lives. The educational reason it matters is that fungi form what is arguably the largest kingdom of higher organisms on the planet. Ignorance of this kingdom is a major blot on our personal education.
Fungi are not bacteria, because fungi are eukaryotes and they have the complex cell structures and abilities to make tissues and organs that we expect of higher organisms.
Ergot is a fungal infection that has infected rye and other plants since farming began. One of the constituents of ergot, the ergot alkaloids, were found to have useful medicinal properties. Ergot was known to cause gangrene in the limbs of those who had ingested infected bread. But later its first medicinal property as a powerful oxytocic (facilitating childbirth) was discovered, and more recently its derivatives have been used in the treatments of migraine. It was the alkaloids of ergot that were found to be the active components in their pharmacological actions, starting with the first pure alkaloid to be isolated, ergotamine. This review covers the history of ergot and the ergot alkaloids and tries to show how ergot went from being just an infection of grass to its alkaloids being the active component in many drugs, especially those in the treatment of migraine. The mechanism of action of the ergot alkaloids is also explained.
Traditional Chinese medicine (TCM) uses many products derived from fungi, including Lentinula edodes (shiitake). Evidence, in the form of published papers, regarding its usefulness has been examined. The review finds that the anti-tumour claims are substantiated, especially those of the lentinan polysaccharide isolated from shiitake. Lentinan is also found to be an immunomodulator, although the medicinal value of these findings are yet to be reliably established. Cholesteremic effects were shown but there was disagreement over the details of the effects. It was concluded that Lentinula edodes does have much potential in medicine but further research is needed.
Our use of fungi is usually hidden from view, so the way we most often directly encounter useful fungi is as part of a meal of mushrooms!
All photographs © David Moore 2011
Mushroom cultivation is important, and I will say more about it below, but it's not the only way we can and do make use of fungi.
Resources for teaching mycology for UK key stages 2, 3 & 4 and post 16.
Website provided by the British Mycological Society
Microbiology online has been devised by the Microbiology Society, the largest learned microbiological society in Europe. This inspirational online resource supports the teaching and learning of microbiology in the classroom across the key stages. It explores how microbes can be friend and foe and most importantly, why we need these invisible organisms to live.