LIVING WITH IT WORKING WITH IT TREATING IT
Just like antibiotics cure bacterial infections, antifungal medications save lives by curing dangerous fungal infections. And just like some bacterial infections are resistant to antibiotics, some fungi no longer respond to the antifungal medications that are designed to cure them. This emerging phenomenon is known as antifungal resistance, and it’s primarily a concern for invasive infections with the fungus Candida but also Aspergillus.
Although antibiotic-resistant bacterial infections are a widely-recognized public health threat, less is known about the effects of antifungal resistance and the burden of drug-resistant fungal infections. This highlights the need for an improved understanding of the reasons for their emergence, heightened awareness among medical and public health communities about these infections, and greater attention to methods that can be used to prevent and control them.
Overall, most serious fungal infections are rare, but they do happen. They are most common among people with weak immune systems. People with certain health conditions may need to take medications with side effects that can weaken your immune system and put you at risk for fungal infections.
Specifically, corticosteroids and TNF (tumor necrosis factor) inhibitors are two types of medications that can increase your chances of getting a fungal infection.1
Some fungal infections can be serious, such as:
Other fungal infections, such as oral candidiasis (thrush), are usually not life threatening.11
Even though you’re staying in the hospital to get better, it’s possible to get an infection while you’re there. If you’re staying in the hospital for an injury or an illness, you may be at risk for getting a fungal infection, especially if you’re very sick or have a weak immune system. These types of infections are calledhealthcare-associated infections (HAIs).
Hospital staff and healthcare providers do everything they can to prevent HAIs, but some procedures and situations can increase your risk for fungal HAIs. The information provided below can help you understand your risk and help you be a safe patient while hospitalized.
Fungal infections can range from mild to life-threatening. Some fungal infections are mild skin rashes, but others can be deadly, like fungal pneumonia. Because of this, it’s important to get treatment as soon as possible to try to avoid serious infection.
Life-saving devices like central venous catheters (a special kind of IV tube) can increase your risk for fungal infection. During your hospital stay you may need a central venous catheter, which is a tube placed into a vein to give medications or liquids. This can make it easier for fungi to enter your body and increase your chances of getting a fungal bloodstream infection such as candidemia.1, 2
Disease-causing fungi can enter your body through cuts, wounds, and burns. Fungi naturally live on your skin and on healthcare workers’ hands. These fungi can enter your body through cuts and wounds and cause infection during a hospital stay, especially if your wounds are severe.3
Staying in the intensive care unit (ICU). If you’re in the ICU because you’re critically ill or injured, you’re likely to need life-saving devices or procedures that can put you at risk for fungal infections, particularly Candida and Aspergillus infections.4
Surgery can lead to infection. If you’ve had surgery, it’s possible to get a fungal infection in in the part of the body where the surgery took place. Surgical site infections are often caused by bacteria, but can also be caused by fungi.
Hospital construction. Hospital staff do everything they can to prevent fungal infections. Despite this, outbreaks of aspergillosis have happened among very sick patients staying at hospitals where there is ongoing construction or renovation.5 This is thought to be because construction stirs up the amount of fungal spores in the air.
As a person living with HIV/AIDS, you have many opportunities for a healthy and full life. You may also have some health challenges. One of those challenges is avoiding infections.
Many fungal infections are called opportunistic infections, which means that they usually affect people with weak immune systems. Because HIV weakens the immune system, you have a greater chance of getting some types of fungal infections, like cryptococcosis, coccidioidomycosis,histoplasmosis, and pneumocystis pneumonia (PCP).
The European Paediatric Mycology Network (EPMyN) was launched in 2014 to create a European platform for research and education in the field of Paediatric Mycology. Its aim is to increase the knowledge of the epidemiology and pathogenesis and to improve the management of invasive fungal infections in neonates and children.
The objectives of the EPMyN are:
Current activities are focussed on collecting the necessary information about the current management of invasive fungal infections in children and neonates from a large number of European centres. This information will be collected by an electronic survey and the data will be captured in the REDCap database. The results of this survey are expected to define specific areas of future research and will emphasize difficulties encountered in our daily practice which need to be addressed.
Our first post-graduate course in Paediatric Mycology is taking place on October 12-13, 2015 in Lisbon, Portugal (just after the Trends in Medical Mycology 2015). This post-graduate course specifically targets paediatric infectious diseases specialists, paediatric hemato-oncologists and immunologists, paediatric pulmonologists and neonatologists (and those in training).
Steering group: Adilia Warris (chair), Andreas Groll, Andrew Cant, Carlo Giaquinto, Elio Castagnola, Emmanuel Roilides, Irja Lutsar, Mike Sharland, Nigel Klein, Paolo Manzoni, Roger Brüggemann, Thomas Lehrnbecher.
Contact: Dr. Adilia Warris, University of Aberdeen, Aberdeen Fungal Group, Institute of Medical Sciences, Rm 4.23, Foresterhill, Aberdeen, AB25 2ZD, UK.
Aspergillus is intensively studied by a range of professional groups; medical, scientific, research, veterinary, taxonomists, genomists.
Some of these researchers are brought together in the Advances Against Aspergillosis meetings that occur once every two years (http://www.advancesagainstaspergillosis.org/) and we thought it would be worthwhile to provide this group to make contact between thses groups more easy between meetings.
Other groups are also welcome to join - all you need is an interest in Aspergillus.
The Aberdeen Fungal Group in partnership with Radboud University Nijmegen, Netherlands secured a Wellcome Trust Strategic Award worth £5.1 million, to establish and lead the Medical Mycology and Fungal Immunology Consortium.
The Consortium also comprises research expertise from Imperial College London and the Universities of Birmingham, Exeter, Glasgow, Kent, Manchester, Newcastle, Sheffield, King's College London, St George's University London and other UK institutions.
Specific Aims of the Consortium:
The International Pediatric Fungal Network is a collaborative group of investigators and centers focused on pediatric invasive fungal infections. This Network is uniquely comprised of expert pediatric investigators dedicated to developing the optimal care for children with these life-threatening infections.
Our mission is to:
Duke University and The Children's Hospital of Philadelphia serve as the coordinating centers for the International Pediatric Fungal Network (IPFN).
The UK Clinical Mycology Network (UKCMN) is a structured network of laboratories with a steering committee to guide and promote best practice in clinical mycology. This is achieved through regular meetings for all members, input into PHE UK Standards for Microbiology Investigations guidelines, and National Institute for Health & Care Excellence guidelines, and co-ordination of the following:
UKCMN’s functions are to:
To find out more, download the UKCMN constitution and terms of reference(PDF, 97.2KB, 2 pages) .
The Fungal Network of New Zealand (FUNNZ) is an independent non-profit incorporated mycological society open to anybody. FUNNZ organises an annual national fungal foray. The main objects of the Society are:
The advent of modern medicine plus AIDS has greatly increased the susceptible population for fungal infection world-wide. Autopsy studies in Europe have shown striking increases in invasive fungal infections, many of which are undiagnosed at death. New antifungal drugs are available, some with better safety profiles than amphotericin B, others with better efficacy but none with uniformly high cure rates. Multiple questions abound – including issues of pharmacodynamics, genetic predisposition, optimal diagnostics, altering epidemiology, combination therapy and many more.
This ESCMID Study Group brings together Europe’s top clinicians, diagnosticians and researchers in invasive fungal infections to create a geographically dispersed critical mass of expertise to address many of these questions.
Many of you will wonder what on earth your Council does for you and ISHAM. Here is a summary of the current Council’s aims and achievements
The current council set as its main priority tackling several recurring problems with the goal of creating a more streamlined, robust and efficient structure for future councils to be better able to represent the interests of the society.
We have by no means met all our goals but we are well on the way of achieving our ambition to secure a promising future for ISHAM in particular and the mycology community in general.
Aspergillus Website listing of all known mycological societies
Raising awareness of the good things that fungi do for all of us.
Fungal diseases can affect anyone. Learning about them can help you and your doctor recognize the symptoms of a fungal disease early and may help prevent serious complications.
Fungal diseases are often caused by fungi that are common in the environment. Most fungi are not dangerous, but some types can be harmful to health.
Mild fungal skin diseases can look like a rash and are very common. Fungal diseases in the lungs are often similar to other illnesses such as the flu or tuberculosis. Some fungal diseases like fungal meningitis and bloodstream infections are less common than skin and lung infections but can be deadly.
All good medical practice follows from an accurate and timely diagnosis. The approach that LIFE takes with respect to improving patient outcomes is a holistic one, but tempered by the realities of each country and region. In some countries, certain fungal infections are common and the emphasis should be on these, and others are rare and are therefore secondary problems to be dealt with. Diagnosis is the cornerstone of good medicine and clinical care.
LIFE aims to reach all medical practitioners and other healthcare professionals who see and treat fungal infections and those who contribute to the diagnosis such as laboratory workers and radiologists. Clinical expertise, and access to diagnostic facilities are all critical to improving outcomes. Likewise access to antifungal therapies is absolutely necessary for almost all serious fungal infections. The website is also provided in Spanish to facilitate international reach. An online course on microscopy and histology for fungal disease will be launched in 2016. Public awareness is also important specifically for some diseases such as SAFS and both skin and mucosal fungal infections.
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FungiMICs is intended as an easy-to-use information source for physicians working in the field of fungal infections. The app aims to provide MIC data and associated clinical breakpoints and epidemiological cut-off (ECOFF) values for different organism–drug interactions, in an intuitive and practical format.