LIVING WITH IT WORKING WITH IT TREATING IT
L’Aspergillose est un terme qui regroupe les infections causées par des champignons appartenant au genre Aspergillus, dont les spores sont véhiculées par l’air et sont inhalées par tous les individus. Totalement inoffensif pour la majorité de la population, ces champignons peuvent cependant provoquer différentes formes de mycoses. L’espèce Aspergillus fumigatus est responsable de plus de 80% des aspergilloses humaines.
The Manchester Fungal Infection Group (MFIG) is a new international centre of excellence for fungal infection biology and translational antifungal research at the University of Manchester. It is integrating its research with that of clinicians and industry.
To understand and reduce the burden of human fungal diseases
With an estimated 1.5 million species, Fungi represent one of the largest branches of the Tree of Life. They have an enormous impact on human affairs and ecosystem functioning, owing to their diverse activities as decomposers, pathogens, and mutualistic symbionts. And perhaps more than any other group of nonphotosynthetic organisms, fungi are essential biological components of the global carbon cycle. Collectively, they are capable of degrading almost any naturally occurring biopolymer and numerous human-made ones. As such, fungi hold considerable promise in the development of alternative fuels, carbon sequestration and bioremediation of contaminated ecosystems.
The use of fungi for the continued benefit of humankind, however, requires an accurate understanding of how they interact in natural and synthetic communities. The ability to sample environments for complex fungal metagenomes is rapidly becoming a reality and will play an important part in harnessing fungi for industrial, energy and climate management purposes. However, our ability to accurately analyze these data relies on well-characterized, foundational reference data of fungal genomes.
To bridge this gap in our understanding of fungal diversity, an international research team in collaboration with the Joint Genome Institute of the Department of Energy has embarked on a five-year project to sequence 1000 fungal genomes from across the Fungal Tree of Life.
A company supporting microbiology & infectious diseases research by providing access to reagents & cultures.
The Protein Data Bank (PDB) archive is the single worldwide repository of information about the 3D structures of large biological molecules, including proteins and nucleic acids. These are the molecules of life that are found in all organisms including bacteria, yeast, plants, flies, other animals, and humans. Understanding the shape of a molecule deduce a structure's role in human health and disease, and in drug development. The structures in the archive range from tiny proteins and bits of DNA to complex molecular machines like the ribosome.
A tool for the layperson to make sense of health studies: Trying to make sense of health research?
This tool will guide you through a series of questions to help you to review and interpret a published health research paper.
Anyone can get a fungal infection, even people who are otherwise healthy. Fungi are common in the environment, and people breathe in or come in contact with fungal spores every day without getting sick. However, in people with weak immune systems, these fungi are more likely to cause an infection.
Infections that happen because a person’s immune system is weak are called opportunistic infections. These illnesses can be caused by bacteria, viruses, or fungi. Many fungal infections are opportunistic infections.
Some people are born with a weak immune system. Others may have an illness that attacks the immune system such as HIV/AIDS. Some medications, like corticosteroids or cancer chemotherapy, can also lower the body’s ability to fight infections.
If you have a weakened immune system, you should be aware that fungal infections can happen. Learning about fungal infections can help you and your doctor recognize them early. This may help prevent serious complications.
As a stem cell transplant patient, you have new opportunities for a healthy and full life. Stem cell transplants have many benefits, but they also have risks. Because stem cell transplants destroy and rebuild your immune system, they increase your risk for fungal infections.
There are two main types of stem cell transplants:
There are different reasons for receiving either type of transplant. You and your healthcare provider will discuss your options and choose the treatment that’s best for you.
A transplant using stem cells from a donor increases your risk for fungal infection more than a transplant that uses stem cells from your own body. If your stem cells come from another person, you will need to take anti-rejection medication. This medication weakens your immune system.1
Chemotherapy and radiation lower your white blood cell count. As you recover from your transplant, your white blood cell count can become very low, also known as neutropenia[PDF - 4 pages]. During this time, your body will have trouble fighting infections, including fungal infections.2
Graft-versus-host disease (GVHD). If you receive stem cells from a donor, the transplanted stem cells may attack your body. This is known as graft-versus-host disease, which can increase your risk for fungal infection.3 The steroid medications given to treat graft-versus-host disease can also increase the chance of getting a fungal infection. 4
Fungal infections can range from mild to life-threatening. Some fungal infections are mild skin rashes, but others can be deadly, like fungal pneumonia. Because of this, it’s important to seek treatment as soon as possible to try to avoid serious infection.
Fungal infections can look like bacterial or viral infections. If you’re taking medicine to fight an infection and you aren’t getting better, ask your doctor about testing you for a fungal infection.
Fungal infections can happen any time after your transplant. Fungal infections can happen days, weeks, or months after the stem cell transplant. If you develop GVHD, you’re at risk for a longer period of time.5
Some types of fungal infections are more common than others in stem cell transplant patients. Aspergillosis is the most common type of fungal infection in stem cell transplant patients, followed by Candida infection and mucormycosis, but other types of fungal infections are also possible.1
Your hospital stay matters. After your transplant, you may need to stay in the hospital for a long time. While there, you may need to have procedures that can increase your chance of getting a fungal infection. Please see the following sites for more information:
Where you live (geography) matters. Some disease-causing fungi are more common in certain parts of the world. If you live in or visit these areas, you may be more likely to get these infections than the general population. For more information on travel-related illnesses, please see the CDC Traveler’s Healthsite.
Indoor mold. You may be at higher risk for getting sick from indoor mold. For more information about indoor mold, please visit CDC's Basic Facts about Mold.
Laboratory of pathogenic fungi has been created as part of the Research Institute of Medical Mycology. PN Kashkina GOU DPO MAPS Medical University as "a central collection of pathogenic fungi of the Russian Federation" Order of the RF Ministry of Health of 28.01.2004, № 19 "On establishment of the Russian collection of pathogenic fungi Ministry of Health of Russia" (with the "Regulations on the Russian collection of pathogenic fungi (RKPG)") . In 2014, the laboratory was renamed in Laboratory "Russian collection of pathogenic fungi" Research Institute of Medical Mycology. PN Kashkina SZGMU Medical University them. II Mechnikov Russian Ministry of Health.
Find out more Fungi are everywhere, and a few species can cause very serious lethal infections. Fungal infections (mycoses) kill more people around the world than malaria. There are no vaccines to protect against fungal infections and we often diagnose them too late to save the patient. Our exhibit spotlights UK research that will help to improve prevention, diagnosis and treatment of mycoses. Across the UK, teams of scientists and doctors are working together to address the huge unmet need for better treatment of fungal infections. We now understand how fungi are recognised by our immune system; paving the way for treatments to boost immune effectiveness, or dampen the damaging inflammation caused by fungal infection. Designing fungus-specific antibiotics is challenging because fungi share many genetic properties with us. However, new drugs may selectively target features of fungi, such as the cell wall. And antibodies are being developed that can be used either for treatment or to assist in early diagnosis. This research is helping to inform and improve clinical options in the worldwide fight against fungal diseases.
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Aimed at Schools Key Stage 2, this website introduces fungi and other micro-organisms to young children
Hello, I'm Dr David Moore and I am a mycologist at the University of Manchester.
Well, let me explain, a mycologist is someone who has studied, and therefore knows quite a lot about fungus. The fungus Kingdom includes mushrooms and yeast and much, much more. As a mycologist, I know the common (Penny Bun) and Latin (Boletus edulis) names of many species of fungi, but more than 100,000 species exist, so I learn more every day! I know how they are classified; what they look like; how they reproduce, feed and grow; how they are used to make medicines (like penicillin and statins) and food (beer, wine, cheese, edible mushrooms, Quorn) and also their dangers such as poisoning and infection. As you can see, mycology is an extremely fascinating and important subject.