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L’Aspergillose est un terme qui regroupe les infections causées par des champignons appartenant au genre Aspergillus, dont les spores sont véhiculées par l’air et sont inhalées par tous les individus. Totalement inoffensif pour la majorité de la population, ces champignons peuvent cependant provoquer différentes formes de mycoses. L’espèce Aspergillus fumigatus est responsable de plus de 80% des aspergilloses humaines.
The Manchester Fungal Infection Group (MFIG) is a new international centre of excellence for fungal infection biology and translational antifungal research at the University of Manchester. It is integrating its research with that of clinicians and industry.
To understand and reduce the burden of human fungal diseases
With an estimated 1.5 million species, Fungi represent one of the largest branches of the Tree of Life. They have an enormous impact on human affairs and ecosystem functioning, owing to their diverse activities as decomposers, pathogens, and mutualistic symbionts. And perhaps more than any other group of nonphotosynthetic organisms, fungi are essential biological components of the global carbon cycle. Collectively, they are capable of degrading almost any naturally occurring biopolymer and numerous human-made ones. As such, fungi hold considerable promise in the development of alternative fuels, carbon sequestration and bioremediation of contaminated ecosystems.
The use of fungi for the continued benefit of humankind, however, requires an accurate understanding of how they interact in natural and synthetic communities. The ability to sample environments for complex fungal metagenomes is rapidly becoming a reality and will play an important part in harnessing fungi for industrial, energy and climate management purposes. However, our ability to accurately analyze these data relies on well-characterized, foundational reference data of fungal genomes.
To bridge this gap in our understanding of fungal diversity, an international research team in collaboration with the Joint Genome Institute of the Department of Energy has embarked on a five-year project to sequence 1000 fungal genomes from across the Fungal Tree of Life.
A company supporting microbiology & infectious diseases research by providing access to reagents & cultures.
The Protein Data Bank (PDB) archive is the single worldwide repository of information about the 3D structures of large biological molecules, including proteins and nucleic acids. These are the molecules of life that are found in all organisms including bacteria, yeast, plants, flies, other animals, and humans. Understanding the shape of a molecule deduce a structure's role in human health and disease, and in drug development. The structures in the archive range from tiny proteins and bits of DNA to complex molecular machines like the ribosome.
A tool for the layperson to make sense of health studies: Trying to make sense of health research?
This tool will guide you through a series of questions to help you to review and interpret a published health research paper.
Overall, most serious fungal infections are rare, but they do happen. They are most common among people with weak immune systems. People with certain health conditions may need to take medications with side effects that can weaken your immune system and put you at risk for fungal infections.
Specifically, corticosteroids and TNF (tumor necrosis factor) inhibitors are two types of medications that can increase your chances of getting a fungal infection.1
Some fungal infections can be serious, such as:
Other fungal infections, such as oral candidiasis (thrush), are usually not life threatening.11
Even though you’re staying in the hospital to get better, it’s possible to get an infection while you’re there. If you’re staying in the hospital for an injury or an illness, you may be at risk for getting a fungal infection, especially if you’re very sick or have a weak immune system. These types of infections are calledhealthcare-associated infections (HAIs).
Hospital staff and healthcare providers do everything they can to prevent HAIs, but some procedures and situations can increase your risk for fungal HAIs. The information provided below can help you understand your risk and help you be a safe patient while hospitalized.
Fungal infections can range from mild to life-threatening. Some fungal infections are mild skin rashes, but others can be deadly, like fungal pneumonia. Because of this, it’s important to get treatment as soon as possible to try to avoid serious infection.
Life-saving devices like central venous catheters (a special kind of IV tube) can increase your risk for fungal infection. During your hospital stay you may need a central venous catheter, which is a tube placed into a vein to give medications or liquids. This can make it easier for fungi to enter your body and increase your chances of getting a fungal bloodstream infection such as candidemia.1, 2
Disease-causing fungi can enter your body through cuts, wounds, and burns. Fungi naturally live on your skin and on healthcare workers’ hands. These fungi can enter your body through cuts and wounds and cause infection during a hospital stay, especially if your wounds are severe.3
Staying in the intensive care unit (ICU). If you’re in the ICU because you’re critically ill or injured, you’re likely to need life-saving devices or procedures that can put you at risk for fungal infections, particularly Candida and Aspergillus infections.4
Surgery can lead to infection. If you’ve had surgery, it’s possible to get a fungal infection in in the part of the body where the surgery took place. Surgical site infections are often caused by bacteria, but can also be caused by fungi.
Hospital construction. Hospital staff do everything they can to prevent fungal infections. Despite this, outbreaks of aspergillosis have happened among very sick patients staying at hospitals where there is ongoing construction or renovation.5 This is thought to be because construction stirs up the amount of fungal spores in the air.
Laboratory of pathogenic fungi has been created as part of the Research Institute of Medical Mycology. PN Kashkina GOU DPO MAPS Medical University as "a central collection of pathogenic fungi of the Russian Federation" Order of the RF Ministry of Health of 28.01.2004, № 19 "On establishment of the Russian collection of pathogenic fungi Ministry of Health of Russia" (with the "Regulations on the Russian collection of pathogenic fungi (RKPG)") . In 2014, the laboratory was renamed in Laboratory "Russian collection of pathogenic fungi" Research Institute of Medical Mycology. PN Kashkina SZGMU Medical University them. II Mechnikov Russian Ministry of Health.
Find out more Fungi are everywhere, and a few species can cause very serious lethal infections. Fungal infections (mycoses) kill more people around the world than malaria. There are no vaccines to protect against fungal infections and we often diagnose them too late to save the patient. Our exhibit spotlights UK research that will help to improve prevention, diagnosis and treatment of mycoses. Across the UK, teams of scientists and doctors are working together to address the huge unmet need for better treatment of fungal infections. We now understand how fungi are recognised by our immune system; paving the way for treatments to boost immune effectiveness, or dampen the damaging inflammation caused by fungal infection. Designing fungus-specific antibiotics is challenging because fungi share many genetic properties with us. However, new drugs may selectively target features of fungi, such as the cell wall. And antibodies are being developed that can be used either for treatment or to assist in early diagnosis. This research is helping to inform and improve clinical options in the worldwide fight against fungal diseases.
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Aimed at Schools Key Stage 2, this website introduces fungi and other micro-organisms to young children
Hello, I'm Dr David Moore and I am a mycologist at the University of Manchester.
Well, let me explain, a mycologist is someone who has studied, and therefore knows quite a lot about fungus. The fungus Kingdom includes mushrooms and yeast and much, much more. As a mycologist, I know the common (Penny Bun) and Latin (Boletus edulis) names of many species of fungi, but more than 100,000 species exist, so I learn more every day! I know how they are classified; what they look like; how they reproduce, feed and grow; how they are used to make medicines (like penicillin and statins) and food (beer, wine, cheese, edible mushrooms, Quorn) and also their dangers such as poisoning and infection. As you can see, mycology is an extremely fascinating and important subject.