Molecular basis of invasive growth during mould infection of the lung

Icheoku Uju Joy1,2, David Moyes2, David Denning1, Elaine Bignell1, Julian Naglik2,

Abstract: 

  • Invasive aspergillosis (IA) is an often fatal mycosis of humans caused by Aspergillus species.
  • Aspergillus fumigatus accounts for more than 90% of all IA cases.
  • Infection occurs primarily via inhalation.
  • Inhaled conidia interact with lung epithelial cells and germinate into hyphae that invade and damage underlying tissues (Fig. 1).
  • The epithelial response during interaction with the fungus is poorly understood; defining the molecular basis of this hostpathogen interaction is the aim of this study.
2016

Poster: 

abstract No: 

P129

Full conference title: 

7th Advances Against Aspergillosis