Aspergillus fumigatus is considered to be the most prevalent airborne pathogenic fungus causing a wide range of diseases in immunocompromised patients. To succeed in the development of the infection, not only does this fungus have to evade and confront the immune system of the host to prevent being swallowed and killed, but it also has to cope with numerous microenvironments. This requires resilience against changes in pH and oxygen levels, and resistance to nutrient limitation and host derived proteins .
Murine models have represented a great breakthrough in the study of the pathogenesis of this fungus and even in antifungal therapy against aspergillosis in recent years. Their results enable the understanding of processes occurring during a real infection and might be extrapolated to human cases.