9-deacetoxyfumigaclavine C

Toxin: 

y

Systematic name: 

Not Known

Molecular formulae: 

C21H28N2

Molecular weight: 

308.46

Chem abstract number: 

1137244-08-6

Literature reference: 

Bioactive Alkaloids from Endophytic Aspergillus fumigatus. Hui Ming Ge , Zhi Guo Yu , Jie Zhang , Jun Hua Wu and Ren Xiang Tan *. J. Nat. Prod., 2009, 72 (4), pp 753–755

Chemical type: 

Alkaloid

Toxicity: 

Cytotoxicity against KB (human nasopharynyeal epidermoid), MCF-7 (human breast adenocarcinoma), and K562 (human leukemia) cancer cell lines. It showed inhibition with an apparent selectivity for K562 cells, with IC50 values of 41.0 ( 4.6 ). It is noteworthy that the activity of metabolite 2 is close to that of doxorubicin hydrochloride (1.2 ( 0.2 μM), a presently prescribed drug for the treatment of leukemia.

Structure image: 

Species known to produce this metabolite: 

Date uploaded: 

2009-04-06 09:51:10